TITLE:
Antispasmodic Effects of Salvia officinalis in Isolated Ileum of Rabbit
AUTHORS:
Wael Al-Aghawani, Isam AL Naser
KEYWORDS:
Salvia officinalis, Isolated Ileum, Verapamil, Carbachol
JOURNAL NAME:
Pharmacology & Pharmacy,
Vol.10 No.5,
May
15,
2019
ABSTRACT: Salvia officinalis has been commonly used in
Syria and other Middle East countries in popular medicine for many medical
purposes. One of the strong claims about its properties is the spasmolytic
effect. The aim of this research was to investigate the spasmolytic effect of
ethanolic extract of Salvia officinalis in isolated rabbit ileum preparations. Male rabbits were sacrificed and
portions of ileum were isolated and mounted in Tyrode’s solution. Afterwards, the experiments were performed according to different groups with different spasmogenic agents: the first group was only with spontaneous contraction, the
second was KCl-induced contractions and the third was Carbachol-induced contractions. The examined extract was added cumulatively in all previous groups. Verapamil was used as
a reference. The results showed profound relaxing effect of S. officinalis extract in mentioned
groups, especially in the group of KCl-induced contraction. These findings suggest that the main mechanism
of the spasmolytic action is related to the inhibition of calcium entry through cell membrane as well as via internal
stores.