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Dey, A. and Cederbaum, A.I. (2007) Geldanamycin, an Inhibitor of Hsp90 Increases Cytochrome P450 2E1 Mediated Toxicity in HepG2 Cells through Sustained Activation of the p38MAPK Pathway. Archives of Biochemistry and Biophysics, 461, 275-286.
https://doi.org/10.1016/j.abb.2007.02.014

has been cited by the following article:

• TITLE: Anti-Inflammatory Activity of Geldanamycin and Its Derivatives in LPS-Induced RAW 264.7 Cells

  AUTHORS: Thongchai Taechowisan, Winyou Puckdee, Watcharee Waratchareeyakul, Waya S. Phutdhawong

  KEYWORDS: Anti-Inflammatory Activity, Geldanamycin Derivatives, Streptomyces zerumbet, RAW 264.7 Cells

  JOURNAL NAME: Advances in Microbiology, Vol.9 No.4, April 29, 2019

  ABSTRACT: Geldanamycin (1) had been isolated as a major compound from Streptomyces zerumbet W14; an endophyte of Zingiber zerumbet (L.) Smith. Two new geldanamycin derivatives; 17-(tryptamine)-17-demethoxygeldanamycin (2) and 17-(5’-methoxytryptamine)-17-demethoxygeldanamycin (3) were synthe- sized and their anti-inflammatory activity was evaluated in LPS-induced macrophage RAW 264.7 cells by investigating their effects on the inhibition of production of NO, PGE2, TNF-α, IL-1β, IL-6 and IL-10. The data obtained were consistent with the modulation of TNF-α, IL-1β, IL-6, IL-10 production by these derivatives at concentration of 1 to 5 μg/ml. A similar effect was also observed when LPS-induced NO release and PGE2 production were tested. The inhibitory effects were shown in concentration-dependent manners. From the obtained results, it was concluded that two new gelda- namycin derivatives possess anti-inflammatory activity on LPS-induced RAW 264.7 cells. They could be useful for the management of inflammatory diseases.