TITLE:
Synthesis and Characterization of a New Compound of Cobalt II with Isonicotinamide and Evaluation of the Bactericidal Potential
AUTHORS:
Anderson Dourado Galvão, Fabricio Tarso de Moraes, Claudia Cristina de Sousa, Kátia Meirelles Duarte de Sousa, Patrícia Gelli Feres de Marchi, Adenilda Cristina Honorio França, Eduardo Luzía França, Wagner Batista dos Santos
KEYWORDS:
Cobalt, Isonicotinamide, Spectroscopy Infrared, TG/DTG and TG/DTA, Bactericidal Activity
JOURNAL NAME:
Open Journal of Inorganic Chemistry,
Vol.9 No.2,
April
28,
2019
ABSTRACT: In this work, the isonicotinamide was coordinated to the Cobalt ion in oxidation state +2. The relevance of this work is the investigation of the in vitro bactericidal potential of the synthesized complex when tested in Gram-positive and negative bacteria strains. This study is motivated by the need to obtain new materials that have antibiotic properties and that, in the future, may become an effective drug against resistant bacteria. A new coordination compound of Cobalt and isonicotinamide, [Co(H2O)(isn)3](BF4)2, was synthesized and described. The compound was characterized by thermoanalytical techniques TG-DTG and TG-DSC, where it was possible to propose the mechanism of thermal decomposition. Through the spectroscopy in the region of the medium infrared (FTIR), it is possible to infer the site of connection between isonicotinamide and metal. The bactericidal activity of [Co(H2O)(isn)3](BF4)2, CoCl2 and free Isonicotinamide were tested for the bacteria Streptococcus mutans (Gram+) and Escherichia coli (Gram−) and the synthesized compound showed to be sensitive for both bacteria.