TITLE:
History of Infection Prior to Hematopoietic Stem Cell Transplant in the Recipient as a Risk Factor to Develop Acute Graft versus Host Disease
AUTHORS:
Alberto Olaya-Vargas, Iván Castorena-Villa, Martin Pérez-García, Gerardo Lopéz-Hernández, Nideshda Ramírez-Uribe, Haydeé Salazar-Rosales
KEYWORDS:
Allogeneic HSCT, Complications, Acute GVHD, HSCT Infections
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.10 No.4,
April
28,
2019
ABSTRACT: Background: Acute graft-versus-host disease (aGVHD) is the most
frequent and severe complication after allogeneic hematopoietic stem cell
transplantation (HSCT). Objective: To determine if a history of prior infection in the allogeneic
HSTC recipient is a risk factor to develop aGVHD. Methods: A
retrospective cohort study based on data collected from the Department
of Hematopoietic Stem Cell Transplantation at the Instituto Nacional de Pediatría
(INP) from January 1998 to December 2016 was performed to identify if prior
infection was a predictive risk factor for aGVHD. Results: 27
patients developed aGVHD (36.4%). Median time to aGVHD presentation was 82 days
(9 to 273 days). Most patients developed grade III aGVHD. Following the
multivariate analysis peripheral blood > bone marrow (OR 12.3; p 8.3 × 106/kg (OR 7.1; p = 0.05), peripheral
blood (OR: 11.4; p Conclusions: Either bacterial infection or CMV infection
in the recipient was significant risk factor
within the aGVHD recipients; it is important to
consider these factors for patients that are going to receive an allogeneic
HSCT.