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Chambers, J.W., Feldman, R.L., Himmelstein, S.I., Bhatheja, R., Villa, A.E., Strickman, N.E., et al. (2014) Pivotal Trial to Evaluate the Safety and Efficacy of the Orbital Atherectomy System in Treating De Novo, Severely Calcified Coronary Lesions (ORBIT II). JACC: Cardiovascular Interventions, 7, 510-518.
https://doi.org/10.1016/j.jcin.2014.01.158

has been cited by the following article:

• TITLE: Coronary Flow Reserve Assessment of Orbital Atherectomy: An Observational Pilot Study

  AUTHORS: Nabil Dib, Brad J. Martinsen, Bynthia M. Anose, John McB. Hodgson, Robert Kohler, Georges Nseir, Nathalie R. Antonios, Richard Shlofmitz, Jeffrey W. Chambers

  KEYWORDS: Percutaneous Coronary Intervention, Microvascular Function, Orbital Atherectomy, Calcified Lesions, Coronary Flow Reserve

  JOURNAL NAME: Journal of Biomedical Science and Engineering, Vol.12 No.4, April 28, 2019

  ABSTRACT: The aim of this prospective observational pilot study was to observe the impact of orbital atherectomy (OA) on the coronary microcirculation via coronary flow reserve (CFR) measurements. Fifteen subjects who had successful OA and stent placement with no procedural complication were enrolled at 3 hospitals in the U.S. Baseline and hyperemic velocities were 16 ± 5.2 and 36 ± 14 cm/sec, respectively. The average CFR post-procedure was within the normal range at 2.23 ± 0.33. The observation of normal CFR following OA may be attributed to the orbital action of the device that allows for continuous flow during treatment, minimizing a bolus embolization effect which can impact microvascular function.