TITLE:
Breast Milk: Its Role in Early Development of the Immune System and Long-Term Health
AUTHORS:
Begüm Harmancıoğlu, Seray Kabaran
KEYWORDS:
Breast Milk, Breast Milk Immunology, Neonatal Immune System, Immune-Mediated Diseases
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.9 No.4,
April
12,
2019
ABSTRACT: Breast milk is the best source of nutrition that provides the energy and nutrients needed for the ideal growth and development of newborns and infants. Besides, breast milk includes various bioactive compounds, which protects infants against infectious agents and antigens and contributes to immune maturation, organ development and microbial
colonization. Breast milk is dynamic; the composition of the nutrients and the content of immunological active compounds may change in each stage of lactation. During the early stages of lactation, biological and immunological active compounds provide additional support to the development of the neonatal immune system. After these stages, the composition of breast milk continues to provide appropriate energy and nutrients according to the infant needs, in order to protect neonatal immune system and maintain the development and growth of infants. Immunological maturation during the fetal life and the
first months of life is provided by immunoglobulins in breast milk, which are among the most important immune protective factors and transferred to infants through breastfeeding. Due to their biological characteristics, Secretory
Immunoglobulin A (SIgA) antibodies are the most important antibodies in breast milk, which provide the first defense against the antigens in the intestines of infants. In addition to antibodies, enzymes, including active leukocytes, cytokines, oligosaccharides, lactoferrin, lysozyme and lactoperoxidase, as well as biological and immunological factors, such as hormones, growth factors, bioactive peptides, nucleotides and fatty acids are transferred to infants through breastfeeding. There is now a growing body of evidence suggesting that breastfeeding protects infants against many infections such as gastrointestinal system and
respiratory tract infections, strengthens immune system and provides protective effects against allergic and autoimmune diseases in later life.