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Ceccato, M.-L., Chenu, J., Méry, J., Follet, M. and Calas, B. (1990) Glycolamidic ester handle used with poly-sty- rene supports. Application to the synthesis of tp5. Tetrahedron Letters, 31, 6189-6192. doi:10.1016/S0040-4039(00)97021-7

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• TITLE: Syntheses and antimicrobial activities of amide derivatives of 4-[(2-isopropyl-5-methylcyclohexyl)oxo]-4-oxobutanoic acid

  AUTHORS: Auj e Sana, Sher Wali Khan, Javid H. Zaidi, Nida Ambreen, Khalid Mohammed Khan, Shahnaz Perveen

  KEYWORDS: Chiral 4-[(2-isopropyl-5-methylcyclohexyl)- oxo]-4-oxobutanoic Acid; Substituted Anilines;Amides; Antimicrobial Activity

  JOURNAL NAME: Natural Science, Vol.3 No.10, October 21, 2011

  ABSTRACT: Chiral 4-[(2-isopropyl-5-methylcyclohexyl)oxo]-4-oxobutanoic acid reacts with substituted anilines to produce amides 1-6 in high yields. Resulted amides 1-6 were investigated for their antifungal and antibacterial activities. Compounds 2 (96.5%) against Aspergillus fumigatus and 6 (93.7%) against Helminthosporium sativum demonstrated excellent activities. However, compounds 3 (37.6%) against Bacillus subtilis, 4 (33.2%) against Pseudomonas aurignosa, 5 against Klebsiella pneumonia demonstrated excellent growth inhibition potential.