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Nwakaso, N., Umejiego, D., Gollapalli, L., Shaeling, A.J. and Lu, L.H. (2008) Targeting a prokaryotic protein in a eukaryotic pathogen: Identification of lead compounds against cryptosporidiosis. Chemistry & Biology, 15, 70- 77. doi:10.1016/j.chembiol.2007.12.010

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• TITLE: Syntheses and antimicrobial activities of amide derivatives of 4-[(2-isopropyl-5-methylcyclohexyl)oxo]-4-oxobutanoic acid

  AUTHORS: Auj e Sana, Sher Wali Khan, Javid H. Zaidi, Nida Ambreen, Khalid Mohammed Khan, Shahnaz Perveen

  KEYWORDS: Chiral 4-[(2-isopropyl-5-methylcyclohexyl)- oxo]-4-oxobutanoic Acid; Substituted Anilines;Amides; Antimicrobial Activity

  JOURNAL NAME: Natural Science, Vol.3 No.10, October 21, 2011

  ABSTRACT: Chiral 4-[(2-isopropyl-5-methylcyclohexyl)oxo]-4-oxobutanoic acid reacts with substituted anilines to produce amides 1-6 in high yields. Resulted amides 1-6 were investigated for their antifungal and antibacterial activities. Compounds 2 (96.5%) against Aspergillus fumigatus and 6 (93.7%) against Helminthosporium sativum demonstrated excellent activities. However, compounds 3 (37.6%) against Bacillus subtilis, 4 (33.2%) against Pseudomonas aurignosa, 5 against Klebsiella pneumonia demonstrated excellent growth inhibition potential.