TITLE:
Synthesis of Folate-Appended β-Cyclodextrin Using Phenanthroline as Linker for Cancer Targeting Drug Delivery
AUTHORS:
Nadim S. Russel, Punam K. Paul, Mohammad Karim, Byeongwoon Song
KEYWORDS:
Schiff Base, β-Cyclodextrin, p-Toluenesulfonylchloride, Ethylenediamine, Folic Acid, 2, 9-Dimethyl-1, 10-Phenanthroline Hemi-Hydrate, 5-(Hydroxymethyl-2-Furaldehyde)
JOURNAL NAME:
International Journal of Organic Chemistry,
Vol.9 No.1,
March
15,
2019
ABSTRACT: Here we have synthesized cancer targeting drug
delivery system that contains β-cyclodextrin
as a drug carrier and folic acid as a targeting ligand. Folic acid was selected
as a cancer targeting ligand because folic acid receptors are highly expressed
in a variety of tumor types. β-cyclodextrin
and folic acid were connected through a linker [1,10-phenanthroline or
5-(hydroxymethyl) furfural]. β-cyclodextrin
and folic acid were attached to the linker by formation of Schiffbase and
ester, respectively. Our targeted synthetic products were confirmed by NMR,
Mass and IR spectroscopy. We anticipate that our synthetic products can confer
cancer cell-specific drug delivery as well as desired properties such as
nanoparticle formation.