TITLE:
Advances in Research on the Pathogenesis of Type 2 Diabetes Complicated with Gallstone
AUTHORS:
Jianchu Tan, Jiguang Kou
KEYWORDS:
Type 2 Diabetes, Gallstones, Pathogenesis
JOURNAL NAME:
International Journal of Clinical Medicine,
Vol.10 No.3,
March
15,
2019
ABSTRACT: At present, the incidence of diabetes complicated with gallstones is increasing rapidly, and there are still many problems in the pathogenesis of the disease. Diabetes complicated with gallstones is a chronic complication of diabetes, with diabetes-induced hyperinsulinemia and insulin resistance, gallbladder emptying disorders, Oddis sphincter dysfunction, gastrointestinal hormone disorders, gastrointestinal dyskinesia, fat metabolism disorders, bile Bacterial infection and other factors are related. In recent years, it has been found that in diabetic patients, Telocytes (TC) and Cajal interstitial cells (ICC) are reduced in the biliary system. In addition, the contact between ICC cells and smooth muscle cells and nerve endings is significantly reduced, so it is considered that bile Stone formation has a certain relationship with TC and ICC reduction. This article reviews recent research progress.