TITLE:
Zinc Oxide Composites of Doxorubicin in the Form of Coating, Composite Films and Gels with a High Antitumor Activity and Low Toxicity
AUTHORS:
Emma R. Arakelova, Stepan G. Grigoryan, Ashot M. Khachatryan, Anahit A. Mirzoian, Zoya M. Farmazyan, Susanna L. Grigoryan, Mkrtich A. Yeranosyan, Flora G. Arsenyan, Rafayel E. Muradyan, Hrachik V. Gasparyan
KEYWORDS:
Zinc Oxide, Magnetron Sputtering, Doxorubicin, Composites, Antitumor Activity
JOURNAL NAME:
Natural Science,
Vol.11 No.3,
March
14,
2019
ABSTRACT: This
work is devoted to the formation doxorubicin (DOX) zinc oxide composites in the
form of coating (DOX + ZnO), hydrogels and composite films of DOX with
polyvinyl alcohol (DOX + PVA + ZnO) by DC-magnetron deposition of ZnO nanoscale
particles (ZnO NPs) on their surfaces (DOX, DOX + PVA) with higher (two times
and more) antitumor activity and considerable smaller toxicity at low doses of
DOX in compositions compared to the initial drug. Using the methods of
spectroscopy, atomic force microscopy (AFM), scanning electron microscopy (SEM)
and X-ray Powder Diffraction (XRD), the role of ZnO NPs size on the antitumor
activity of doxorubicin zinc oxide compositions is shown. AFM shows presence of
many ZnO NPs on the surface DOX. A comparison of the FTIR spectra of DOX and
its zinc oxide compositions has shown the presence of new bands of OH valence
and deformation vibrations. It is possible to assume that interaction between
ZnO and DOX takes place in the form of hydrogen bond, promoting the complexes
formation. It is possible that both synergic and hydrogen-bonding ZnO with DOX
increase the antitumor activity.