TITLE:
Kanggan Granule Ameliorates Dexamethasone-Induced Immunosuppression in Mice
AUTHORS:
Yumiao Gan, Manxia Gu, Dongling Liu, Hongjing Zhou, Chenye Zeng, Tingting Yang, Hui Li, Funeng Geng, Junrong Du
KEYWORDS:
Kanggan Granule, Immunomodulatory, Nonspecific Immunity, Humoral Immunity, Cellular Immunity
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.7 No.3,
March
14,
2019
ABSTRACT: Objective: This
study was to investigate the effect of the Chinese herbal compound Kanggan
granule (KG) on immune function in a mouse model of immunosuppression and its
possible mechanism of action. Method: ICR mice were randomly divided into a normal control group (untreated
non-immunosuppressed, Control), untreated immunosuppressed group (Model), positive control group (immunosuppressed and treated with 1.6 g/kg astragalus
granule [AG]), high-dose KG group (immunosuppressed and treated with 24 g/kg,
KG-24), and low-dose KG group (immunosuppressed and treated with 6 g/kg, KG-6).
Each group received intragastric administration once daily for 7 days.
Immunosuppression was induced by an intraperitoneal injection of dexamethasone
(25 mg/kg) once daily beginning on day 1 for 3 days. To illuminate the
mechanism of immunomodulatory, we studied the effects of KG on nonspecific
immunity, humoral immunity and cellular immunity in mice respectively. Results: KG improved organ weights and improved the phagocytic ability of mononuclear
macrophages in immunosuppressed mice (p p p +/CD8+ ratio in immunosuppressed mice (p p Conclusions: KG can improve immune function in
immunosuppressed mice. Nonspecific immunity, humoral immunity, and cellular
immunity were all enhanced.