TITLE:
Carbon Nanoparticles for Identifying Lymph Nodes during Surgery in Colorectal Cancer: A Meta-Analysis
AUTHORS:
Miao Liu, Ai Shen, Wei Li, Lihui Chen, Xiufeng Chen, Hao Sun
KEYWORDS:
Carbon Nanoparticles, Lymph Node, Colorectal Cancer
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.10 No.2,
February
15,
2019
ABSTRACT: Aim: To investigative the efficacy of carbon nanoparticles (CNs) to
identify the lymph nodes during radical surgery in colorectal cancer. Method: The
MEDLINE, EMBASE and Cochrane Library databases were searched electronically to identify
the studies that compared the use of CNs (CN group) with control group in
patients undergoing colorectal cancer radical surgery (from January 2009 to
November 2018). The primary outcome was the number of retrieved central lymph
nodes. Results: This meta-analysis identified 2 randomized controlled trials
and 5 non-randomized controlled trials. Compared with the control group, the CN
group resulted in an average of 7.16 more lymph nodes removed per patient (WMD
= 7.16, 95% CI = 3.76 to 10.57, p p = 0.02), and 15.1 ml less blood loss during operation (WMD = -15.11, 95% CI = -23.15
to -7.06, p p = 0.87), there was 1.45 times more metastatic lymph of the
stained nodes in CN group than in the control group (OR = 1.45, 95% CI = 1.13
to 1.85, p 5 mm were detected significantly more in the CN group than in the control
group (OR = 2.15, 95% CI = 1.77 to 2.63, p s higher risk of metastasis. Further high quality RCT is needed to verify
these conclusions.