TITLE:
The Area under the Curve (AUC) of Oral Glucose Tolerance Test (OGTT) Could Be a Measure Method of Hyperglycemia in All Pregnant Women
AUTHORS:
Congyue Zhang, Yumei Wei, Weijie Sun, Huixia Yang
KEYWORDS:
AUC, GDM, OGTT, Measure Method, Hyperglycemia
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.9 No.2,
February
11,
2019
ABSTRACT: Objective: We adopted the area under the curve (AUC) of oral
glucose tolerance test (OGTT) as a measure method of the severity of maternal
hyperglycemia and investigated its relationship with adverse perinatal outcomes
among women with and without gestational diabetes mellitus (GDM). Research
design and methods: This is a retrospective cohort
study. Our study group collected the medical records of 15,296 women who
received perinatal care in 15 hospitals in
Beijing and who delivered from July 1, 2013, to December 31, 2013. And several
original articles on this cohort have been published. In this study, we analyze the relationship between
AUC and adverse perinatal outcomes, so that in multiple
pregnant cases, patients with pre-pregnancy diabetes,
hypertension, and abnormal kidney function and those who did not receive a 75-g OGTT were
excluded. A Chi-squared test and logistic regression analysis were used to determine the
associations. Results: In total, 13,561 women were included. As the AUC
of OGTT increased, the prevalence of macrosomia (odds ratio [OR] 1.059, 95% confidence interval [95% CI]
1.029 - 1.090, p Women with an AUC higher than 14.20 (mmol * h/L) had a higher risk of adverse outcomes regardless of the presence of
GDM. Conclusions: The AUC could be a
measure method of the severity of maternal hyperglycemia, and women with a high
AUC should undergo aggressive management to avoid adverse outcomes regardless
of the presence of GDM.