TITLE:
The Impact of Human Parvovirus B19 Co-Infection on Liver Function of HCV Infected Patients
AUTHORS:
Mohamed Nabil, Mohammed H. Saiem Al-Dahr, Waleed Abu Al-Soud, Omar Alfaruok
KEYWORDS:
Parvovirus B19, HCV, Co-Infection, ALT and AST
JOURNAL NAME:
Open Journal of Applied Sciences,
Vol.9 No.1,
January
28,
2019
ABSTRACT: Background:
Human Parvovirus B19 is most known for causing disease in the pediatric
population but can also affect adults. Human co-infection with Parvovirus B19
could deteriorate the prognosis of patient with chronic ill-ness.
Objectives:
This paper attempts to determine the prevalence of Parvovirus B19 in HCV
infected patients and to evaluate the impact of Parvovirus B19 on liver enzymes
activity of Hepatitis C patients. Study Design: The study population includes
74 chronic HCV (patient group) and 49 cases without viral hepatitis (control
group). Nucleic acid of Parvovirus B19 was detected in Serum samples by nested
polymerase chain reaction (nested-PCR) method. Results: Parvovirus B19-DNA
infection was detected in 28.0% of chronic HCV patients. Parvovirus B19-HCV
co-infection caused increasing in Alanine aminotransferase (ALT) and Aspartate
aminotransferase (AST) activity than in B19-negative HCV patients. Conclusion:
We conclude that Parvovirus B19 acted synergistically with HCV by increasing
the levels alanine ami-notransferase (ALT) and Aspartate aminotransferase
(AST).