TITLE:
Level of Fasting C-Peptide as a Predictor of β-Cell Function in Sudanese Patients with Type 2 Diabetes Mellitus
AUTHORS:
Hani Yousif Zaki, Ahmed Abbi Abdille, Badreldin Elsonni Abdalla
KEYWORDS:
β-Cell Function, C-Peptide, Insulin Resistance, Type 2 Diabetes Mellitus
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.7 No.1,
January
25,
2019
ABSTRACT: Objective: In this
study, we assessed the level of fasting C-peptide as a predictor of β-cell function and insulin resistance
in patients with Type 2 diabetes mellitus (T2DM), Gezira State-Sudan. Methods: In this cross-sectional study, 100 T2DM patients attending the Diabetic
patients care Centre were recruited, thirty five patients were males and sixty
five were females, the mean age of the patients was 50.29 ± 0.456 years, and
body mass index (BMI) was 26.54 ± 0.437. We estimated β-cell function using fasting C-peptide levels; homeostatic model
assessment for β-cell function (HOMA-B)
and insulin resistance (HOMA-IR) were calculated from C-peptide and fasting
blood glucose (FBG). Results: C-peptide was significantly and positively
correlated with HOMA-B and HOMA-IR. FBG also showed significant negative
correlation with HOMA-B, but was positively and significantly correlated with
HOMA-IR. HbA1c was negatively and significantly correlated with HOMA-B.
Patients with low C-peptide levels had increased FBG and HbA1c level, while
patients with high C-peptide levels were having high HOMA-IR and HOMA-B. Conclusions: Fasting C-peptide is a useful marker of pancreatic β-cell function, and its circulating levels could be used to
evaluate insulin secretion and insulin resistance. Moreover, HOMA-IR is an
effective index to achieve glycemic control by appropriate pharmacologic
treatment of T2DM.