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Bouchard, C., Rankinen, T., Chagnon, Y.C., Rice, T., Pérusse, L., Gagnon, J., Borecki, I., An, P., Leon, A.S., Skinner, J.S., Wilmore, J.H., Province, M. and Rao, D.C. (2000) Genomic Scan for Maximal Oxygen Uptake and Its Response to Training in the HERITAGE Family Study. Journal of Applied Physiology, 88, 551-559.
https://doi.org/10.1152/jappl.2000.88.2.551

has been cited by the following article:

• TITLE: Peak O2 Uptake Correlates with Fat Free Mass in Athletes but Not in Sedentary Subjects

  AUTHORS: Jasem Ramadan AlKandari, Mario Barac Nieto

  KEYWORDS: VO2max, Lean Body Mass, Physical Activity, Age, Regression Analysis

  JOURNAL NAME: Health, Vol.11 No.1, January 15, 2019

  ABSTRACT: Objective: To characterize relationships between peak O2 uptake (VO2max) and fat free mass (FFM) in adult sedentary and in young and adult athletes. Methods: Healthy adult male sedentary workers or students reporting no regular physical activity in the last six months (n = 61, 31.0 ± 0.95 years) and young (n = 63, 15.8 ± 0.16 years) or adult (n = 85, 25.9 ± 0.48 years) males athletes were studied. Sports were classified according to their MET intensity. Bruce’s treadmill protocol served to measure VO2max. Weight and seven skin-fold thicknesses were used to estimate body density and FFM. Subjects signed informed-consent forms before the tests. Results: The significant correlations (R2 = 0.48, p 2max or of log FFM with log VO2max (R2 = 0.53, p 2 = 0.34 & 0.30), and not significant (R2 = 0.19 & 0.17, p > 0.05) in sedentary subjects. Stepwise multiple regression analysis (R2 = 0.65) indicated that VO2max depended on FFM, heart rates and MET intensity of practiced sport in athletes. In sedentary subjects VO2max was insignificantly (R2 = 0.18) related to flexibility. Discussion: Skin-fold based FFM reliably reflects maximally active muscle mass in young athletes, to a lesser extent in adult athletes but not in adult sedentary subjects. In sedentary, VO2max is often limited by local pain and fatigue and does not reflect the capacity of the oxygen extraction system. In sedentary, varying proportions of surface fat, muscle and bone increase variability in the relationship between skinfolds and FFM.