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Shamseldin, H.E., Alasmari, A., Salih, M.A., Samman, M.M., Mian, S.A., Alshidi, T., Ibrahim, N., Hashem, M., Faqeih, E., Al-Mohanna, F., et al. (2017) A Null Mutation in MICU2 Causes Abnormal Mitochondrial Calcium Homeostasis and a Severe Neurodevelopmental Disorder. Brain, 140, 2806-2813.
https://doi.org/10.1093/brain/awx237

has been cited by the following article:

• TITLE: Effect of Calcium Consumption on the Spasticity in the Spastic Rats

  AUTHORS: Marina Indriasari, Hardinsyah, Lilik Kustiyah, Bambang Pontjo Priosoeryanto, Ferial Hadipoetro Idris

  KEYWORDS: Calcium, Consumption, Spasticity

  JOURNAL NAME: Food and Nutrition Sciences, Vol.10 No.1, January 14, 2019

  ABSTRACT: Spasticity is a stiff muscle condition because the muscles receive impulses continuously. Calcium ions play a role in the ability of nerves to stimulate muscle contraction. This study aimed to analyze the effect of calcium consumption on the changes of spasticity and the relation of calcium levels in the blood and muscle to the spasticity. The experimental study was conducted on 42 male Sprague-Dawley rats aged 12 - 14 weeks. The 15-d intervention was conducted on six groups of spastic rats by administering 20 g of feed containing 50 mg, 100 mg, and 200 mg of calcium, it also received 100 mg, 200 mg, and 300 mg of calcium lactate supplementation. The experimental rats were induced with 80 mg/kg BW of Erythrocin B through the tail vein to make them spastic. This study showed a tendency of increased spasticity along with the increased dose of calcium given to the subjects. There were significant differences (p = 0.007) in changes in spasticity between groups. The significant differences (p = 0.02) in changes in blood calcium levels. The Spearman’s correlations test on the changes in blood calcium levels and changes in spasticity showed a positive coefficient correlation (r = 0.097) with a p-value of 0.54. An increase in blood calcium levels and a large decrease in spasticity were found in the group receiving 100 mg calcium intake in 20 g of feed. The calcium levels in muscles had a significant correlation with spasticity (p = 0.038, r = 0.810). The calcium levels in the muscle had a strong correlation with blood calcium levels (p = 0.041, r = 0.748). The biggest decrease in spasticity occurred after 100 mg of calcium were given to the rats for 15 days, and it was considered as an optimal dose. The calcium levels in the muscles had a strong correlation with blood calcium levels and the spasticity of the spastic rats.