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San, L., Cami, J., Peri, J.M., Mata, R., Porta, M. and Camí, J. (1990) Efficacy of Clonidine, Guanfacine and Methadone in the Rapid Detoxification of Heroin Addicts: A Controlled Clinical Trial. British Journal of Addiction, 85, 141-147.
https://doi.org/10.1111/j.1360-0443.1990.tb00634.x
has been cited by the following article:
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TITLE:
Differences in the Receptor Binding Profile of Lofexidine Compared to Clonidine
AUTHORS:
Robert B. Raffa, Joseph V. Pergolizzi, Robert Taylor, Robert P. James, Mark Pirner
KEYWORDS:
Lofexidine, Clonidine, Opioid Withdrawal, Receptor Affinity, Alpha-2 Agonist
JOURNAL NAME:
Pharmacology & Pharmacy,
Vol.10 No.1,
January
3,
2019
ABSTRACT: Lucemyra? (lofexidine hydrochloride) has recently
been approved by the US FDA for the mitigation of withdrawal symptoms to
facilitate abrupt discontinuation of opioids in adults. Lofexidine is an
alpha-2 adrenoceptor agonist. However, the clinical attributes of lofexidine
differ in advantageous ways from the classical alpha-2 adrenoceptor agonist
clonidine. In the present study, we measured the receptor binding profile of
lofexidine and clonidine in an effort to gain an insight into the clinical
difference(s).