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Eason, M.G., Kurose, H., Holt, B.D., Raymond, J.R. and Liggett, S.B. (1992) Simultaneous Coupling of Alpha 2-Adrenergic Receptors to two G-Proteins with Opposing Effects. Subtype-Selective Coupling of Alpha 2C10, Alpha 2C4, and Alpha 2C2 Adrenergic Receptors to Gi and Gs. Journal of Biological Chemistry, 267, 15795-15801.

has been cited by the following article:

• TITLE: Differences in the Receptor Binding Profile of Lofexidine Compared to Clonidine

  AUTHORS: Robert B. Raffa, Joseph V. Pergolizzi, Robert Taylor, Robert P. James, Mark Pirner

  KEYWORDS: Lofexidine, Clonidine, Opioid Withdrawal, Receptor Affinity, Alpha-2 Agonist

  JOURNAL NAME: Pharmacology & Pharmacy, Vol.10 No.1, January 3, 2019

  ABSTRACT: Lucemyra? (lofexidine hydrochloride) has recently been approved by the US FDA for the mitigation of withdrawal symptoms to facilitate abrupt discontinuation of opioids in adults. Lofexidine is an alpha-2 adrenoceptor agonist. However, the clinical attributes of lofexidine differ in advantageous ways from the classical alpha-2 adrenoceptor agonist clonidine. In the present study, we measured the receptor binding profile of lofexidine and clonidine in an effort to gain an insight into the clinical difference(s).