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Scheppach, W., Sommer, H., Kirchner, T., Paganelli, G.M., Bartram, P., Christl, S., et al. (1992) Effect of Butyrate Enemas on the Colonic Mucosa in Distal Ulcerative Colitis. Gastroenterology, 103, 51-56. https://doi.org/10.1016/0016-5085(92)91094-K

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• TITLE: Yacon Product (PBY) Modulates Intestinal Constipation and Protects the Integrity of Crypts in Wistar Rats

  AUTHORS: Mônica de Souza Lima Sant’Anna, Vivian Carolina Rodrigues, Tatiane Ferreira Araújo, Tânia Toledo de Oliveira, Maria do Carmo Gouveia Pelúzio, Célia Lúcia de Luces Fortes Ferreira

  KEYWORDS: Prebiotic, Yacon, Single Chain Fatty Acid, Constipation

  JOURNAL NAME: Food and Nutrition Sciences, Vol.9 No.12, December 28, 2018

  ABSTRACT: This study investigated the use of a product based on yacon (PBY) in microbiological, physical-chemical and intestinal characteristics of Wistar rats artificially constipated with Loperamide®. Thirty-two rats were divided into four groups: Control (C), Constipated Control (CC), PBY (not constipated) and Constipated PBY (PBYC). The dosage of 0.14 g of FOS+ inulin/kg was tested. Microbiota, pH and faeces characteristics of faeces and caecal contents were evaluated. Caecal weight, morphometry of caecal villi and the concentration of short-chain fatty acids were determined. Higher caecal weight was identified in the PBYC animals as well as higher width, height and depth of cripts. The PBY group showed the highest (p