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Spelman, K., Burns, J., Nichols, D., Winters, N., Ottersberg, S. and Tenborg, M. (2006) Modulation of Cytokine Expression by Traditional Medicines: A Review of Herbal Immunomodulators. Alternative Medicine Review, 11, 128-150.

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• TITLE: Renoprotective and Blood Pressure Lowering Impact of Equisetum arvense and Viscum album Therapy in Experimental Model of Chronic Kidney Disease

  AUTHORS: Ülle Pechter, Ingrid Kalev, Mai Ots-Rosenberg

  KEYWORDS: Equisetum arvense, Experimental Chronic Kidney Disease, MCP-1 Relative Transcription, Viscum album

  JOURNAL NAME: World Journal of Cardiovascular Diseases, Vol.8 No.12, December 24, 2018

  ABSTRACT: Background: Chronic kidney disease (CKD) is an irreversible decline in the glomerular filtration due to nephrosclerosis and glomerular loss. Rat remnant kidney model enables to assess the benefits of different treatment possibilities. Aim: The aim of our study was to investigate renal morphology and functioning after 12 weeks of treatment with Equisetum arvense and Viscum album. Methods: Male Wistar rats with 5/6 nephrectomy received herbal drug preparation Equisetum/Viscum in a dosage of 0.007 g/kg/die (herbal group) or losartan (180 mg/l, ARB group) or remained untreated. Systolic blood pressure (SBP) and proteinuria were measured. Renal cortex tissue samples examined for focal-segmental glomerulosclerosis (FSGS) and interstitial fibrosis (IF). mRNA was isolated to estimate CCL2/MCP-1 gene transcription. Results: SBP was significantly lower both in herbal group and ARB group compared with untreated animals (p between ARB group and untreated NPX (p = 0.001). Quantitative RT-PCR analysis revealed statistically significant differences of mRNA transcription for MCP-1 between herbal group and untreated group (p Conclusions: We report about beneficial impact of horsetail Equisetum arvense and mistletoe Viscum album treatment on kidney functioning and morphology.