TITLE:
Effect of Vitamin D Supplementation on Intracytoplasmic Sperm Injection Outcomes: A Randomized Double-Blinded Placebo-Controlled Trial
AUTHORS:
Ahmed H. Abd-Ellah, Abd El-Naser Abd El-Gaber Ali, Mustafa M. Khodry, Mahmoud I. El-Rasheedy, Ahmed M. Abbas
KEYWORDS:
Vitamin D, Intracytoplasmic Sperm Injection, ICSI
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.8 No.14,
December
21,
2018
ABSTRACT: OBJECTIVE: To assess the effect of
vitamin D supplementation on enhancement of
embryos implantation rates in intracytoplasmic sperm injection procedures. STUDY DESIGN: A randomized double-blinded controlled
trial. SETTING: Assisted Reproduction Unit of Obstetrics and Gynecology
Department, Faculty of Medicine, South Valley University, Egypt. DURATION: From December 1st 2017
to the end of October 2018. SUBJECTS and METHDS: Eighty
infertile couples that underwent ICSI procedure were entrapped in this study. Patients were divided into
two groups; Group I (Vitamin D group) = 40
patients (received vitamin D supplementation in the form
of Vidrop oral drops 600 IU/day starting after ovum pickup) and Group II
(placebo group) = 40 patients (received a placebo “normal saline oral drop”). RESULTS: There was a significantly increased embryo
implantation rates (53.2%
in vitamin D group versus 46.7% in placebo group), there was a mild
statistically significant difference in the clinical pregnancy rates (45.9% in vitamin D group versus 39.4% in
placebo group) with p-value CONCLUSIONS: Vitamin D supplementation
could improve embryos implantation rates and rate of ongoing pregnancy by
decline in the first trimester miscarriage rate.