TITLE:
The Beneficial Effect of Enriched Environment on Pathogenesis of Alzheimer’s Disease
AUTHORS:
Xingxing Chen, Jie Hu, Anbang Sun
KEYWORDS:
Alzheimer’s Disease, Enriched Environment, Microtubule Associated Protein Tau, β-Amyloid Precursor Protein, Neurogenesis
JOURNAL NAME:
Yangtze Medicine,
Vol.2 No.4,
December
21,
2018
ABSTRACT: Alzheimer’s disease (AD) is a common neurodegenerative disease, its main clinical symptoms are the progressive decline of cognitive and memory functions. Enriched Environment (EE) achieves the goal of improving brain cognitive reserve by enhancing the multi-directional stimulation on movement, sensory and cognitive systems of animals. And EE can regulate the levels of various trophic factors in the brain, promote synaptic regeneration and enhance neural plasticity to reduce the loss of neurons induced by inflammation. At present, there is still no effective treatment for AD and the clinical intervention drug is expensive. So it is essential to actively explore non-drug treatment. This review will explain the effects of EE on learning ability, memory ability and mental behavior in AD, and provide a new direction for the treatment and rehabilitation of AD.