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Bennett, J.J., Tjuvajev, J., Johnson, P., Doubrovin, M., Akhurst, T., Malholtra, S., Hackman, T., Balatoni, J., Finn, R., Larson, S.M., Federoff, H., Blasberg, R. and Fong, Y. (2001) Positron Emission Tomography Imaging for Herpes Virus Infection: Implications for Oncolytic Viral Treatments of Cancer. Nature Medicine, 7, 859-863.

has been cited by the following article:

• TITLE: Oncolytic Herpes Simplex Virus ICP47 Deletion Reverses Tumor Immune Evasion

  AUTHORS: Junting Cheng, Yingying Wang, Ying Zhang, Wenqi Cai, Yang Zhou, Ziwen Han, Xiaoqin Liu, Xianwang Wang, Xiaochun Pen, Ying Xiang, Zhaowu Ma, Hongwu Xin

  KEYWORDS: Oncolytic Virus, HSV, ICP47, Anti-Tumor Immunity

  JOURNAL NAME: Yangtze Medicine, Vol.2 No.4, December 21, 2018

  ABSTRACT: Herpes simplex virus (HSV) is an enveloped, double-stranded DNA virus that has been used with modification as oncolytic viruses (OVs) against a number of tumor types. OVs represent a new class of therapeutic agents that promote anti-tumour responses through a dual mechanism of action that is dependent on selective tumor cell killing and the induction of systemic anti-tumour immunity. Among OVs, HSVs preferentially replicate in and lyse cancer cells, leading to in situ autovaccination, adaptive anti-virus and anti-tumor immunity. Suppression of antitumor immunity after OV therapy has been observed and the molecular and cellular mechanisms of action are recently reported. ICP47, a small protein produced by the herpes simplex virus, is considered as an important factor in the evasion of cellular immune responses in HSV-infected cells. Therefore, reviewing the research status of ICP47 is certainly helpful to improve the anti-tumor effect of oncolytic HSVs (oHSVs). Here, this review will focus on the following contents: 1) Anti-tumor mechanism of OVs; 2) Functions of early HSV genes; 3) The mechanism of immune escape of ICP47; 4) Recombinant HSV against cancer; 5) The functional verification of ICP47 deletion. This review highlights the current understanding of recombinant HSVs against cancers.