TITLE:
Biomarkers and Echocardiography in the Postoperative Course of Pulmonary Resection Surgery
AUTHORS:
David Andaluz-Ojeda, Francisco Gandía, Jose Luis Duque, Itziar Gómez, Begona De Gregorio, Jose Alberto San Román, Eduardo Villacorta
KEYWORDS:
Pneumonectomy, Lobectomy, Echocardiography, Right Ventricle, Natriuretic Peptides, C reactive Protein, T Troponine, Biomarkers
JOURNAL NAME:
Open Journal of Thoracic Surgery,
Vol.1 No.1,
September
20,
2011
ABSTRACT: Background: The existence of different degrees of inflammatory reaction and right ventricular dysfunction after pulmonary resection is well known, though its detection and clinical relevance have not been sufficiently evaluated. The introduction of new biomarkers, particularly brain natriuretic peptide (BNP) and its prohormone (proBNP), together with dynamic imaging techniques such as echocardiography, could prove useful in assessing such response. The aim of this study is to describe the kinetic curve of these biomarkers during uncomplicated pulmonary resection surgery. Furthemore we have studied the right ventricular function by echocardiography in these patients
Methods: Demographic data, antecedents and certain perioperative parameters, as well as plasma proBNP, troponin T and C-reactive protein (CRP) levels, were recorded in 38 patients who underwent pneumonectomy (n= 13 ) and lobectomy (n=25), before and 24, 48 and 72 hours after the operation. A transthoracic echocardiogram was carried out preoperatively and 72 hours after surgery.
Results: ProBNP showed a significant increase 24 hours after surgery, with a maximum peak after 72 hours (p