TITLE:
Synthesis of New Fluorinated Amino-Heterocyclic Compounds Bearing 6-Aryl-5-Oxo-1,2,4-Triazin-3-Yl Moiety as Antimicrobial Agents
AUTHORS:
Wafa A. Bawazir, Reda M. Abdel-Rahman
KEYWORDS:
Facile Synthesis, Fluoro-Amino-1, 2, 4-Triazines, Antimicrobials
JOURNAL NAME:
International Journal of Organic Chemistry,
Vol.8 No.4,
December
7,
2018
ABSTRACT: Some more new fluorine substitutedamino compounds bearing
6-aryl-5-oxo-1,2,4-triazin-3-yl moieties and its derivatives 3 - 7 have been synthesised successfully from aroylation of
6-(2’-aminophenyl)-3-thioxo-1,2,4-triazin-5-one (1), followed by fluoro amination with 4-fluoroanilinein Abs EtOH and then treated with ammonia/EtOH and finally acylation/aroylation or cyclocondensation reactions with malonic acid in AcOH. Structure of the products has been established upon elemental analysis and their spectral measurements. All the obtained compounds evaluated as antimicrobial agents were the compounds which contained both nitro and fluorine elements and exhibited a highly activity the other derivatives.