TITLE:
Serum Neopterin as a Novel Marker for Carotid Artery Stenosis in Community Subjects
AUTHORS:
Huanquan Liao, Zhichao Yan, Hongxuan Wang, Hua Hong
KEYWORDS:
Neopterin, Carotid, Carotid Artery Stenosis, Ultrasound
JOURNAL NAME:
Open Access Library Journal,
Vol.5 No.12,
December
4,
2018
ABSTRACT: Background: Carotid artery stenosis (CAS) is one of the major high-risk mechanisms of stroke. Neopterin, an immune modulator secreted by macro-phages, has been reported to be elevated in patients with cerebrovascular dis-ease. However, an association between serum neopterin level and CAS has not been firmly established. Objective: To investigate the cross-sectional relation-ship between serum neopterin levels and CAS assessed by ultrasound. Meth-ods: The study participants were volunteers in a community-based cohort aim-ing to prevent stroke in Guangzhou. Bilateral carotid artery ultrasonography was performed to assess the carotid atherosclerosis. After participant criterion screening and random sampling, finally 140 subjects were studied in our pre-sent study. Enzyme-linked immunosorbent assay was performed to measured serum neopterin concentrations. Results: Neopterin level in the CAS and con-trol group was 5.4 (3.3 - 7.3) nmol/L and 4.6 (3.6 - 5.4) nmol/L respectively, with a significant difference (P