TITLE:
Free Radical Activity as Diagnostic and Prognostic Criteria in Solid Tumors and Their Therapy
AUTHORS:
E. I. Erlykina, L. M. Obukhova, T. V. Kopytova
KEYWORDS:
Free Radical Activity, Oxidative Modification, Blood Plasma Proteins, Cancer, Chemotherapy Efficiency
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.6 No.12,
November
30,
2018
ABSTRACT: Blood
plasma of 39 cancer patients who had not previously undergone anti-tumor
treatment, and 21 patients with recurrent epithelial tissues cancer before
treatment and after the first course of chemotherapy were investigated. The
treatment effectiveness of patients with relapse was evaluated throughout the
year. The control group was the blood plasma of 14 healthy people. Free radical
activity and oxidative modification of proteins were assessed in blood plasma.
In malignant neoplasms of epithelial tissues, free radical activity and
oxidative modification of plasma proteins are significantly higher. At the
initial stages of carcinogenesis, the oxidative modification level of plasma
proteins increases both due to aldehyde and ketone carbonyl derivatives. In the
terminal stage of malignant tumors, an increase in the oxidative modification
of proteins occurs due to aliphatic ketone dinitrophenyl hydrazones, which are
the markers of protein aggregation characteristic of the late stages of
oxidative stress. In case of an objective response to polychemotherapy, there
is a significant decrease in free radical plasma activity after the first
course of therapy and a significant increase in carbonyl derivatives recorded
at a wavelength of 230 nm, which can serve as a marker of its effectiveness.