TITLE:
A Mild and Efficient Method for the Synthesis of Acylals from Aromatic Aldehydes and Their Deprotections Catalyzed by Synthetic Phosphates under Solvent-Free Conditions
AUTHORS:
Fathallaah Bazi, Bahija Mounir, Mohammed Hamza, Said Sebti
KEYWORDS:
Synthetic Phosphates, Clean Process, Acylals, Protection, Deprotection
JOURNAL NAME:
Green and Sustainable Chemistry,
Vol.8 No.4,
November
30,
2018
ABSTRACT: An efficient and clean preparation of acylals from aromatic aldehydes in the presence of synthetic phosphates (flourapatite and hydroxyapatite doped with ZnCl2 and ZnBr2) and acetic anhydride was achieved easily in high yields (86% - 97%) at room temperature under solvent-free conditions. Deprotection of the resulting acylals has also been attained by using the same catalysts under microwave irradiation. This method consistently has advantage of excellent yields (82% - 96%) and a short reaction time (3 - 4 min).