Article citationsMore>>

The Notably Lower Mass in Figure 2 of the Separated Aqueous Phase from the pH 8.7 Cream May Be an Artifact and Is Being Further Investigated to Determine Significance.

has been cited by the following article:

• TITLE: Characterization of a Liquid Crystal Stabilized Pharmaceutical Oil-in-Water Emulsion Optimized for Skin Delivery

  AUTHORS: Melinda J. Sutton, David W. Osborne, Kevin Dahl, Victoria Bax, G. Alan Schick

  KEYWORDS: Pharmaceutical Emulsion, Skin Delivery, Liquid Crystal Stabilized Emulsion, Polarized Light Microscopy, Topical Formulation

  JOURNAL NAME: Journal of Cosmetics, Dermatological Sciences and Applications, Vol.8 No.4, November 16, 2018

  ABSTRACT: A moisturizing cream containing 25 wt% of an organic solvent, diethylene glycol monoethyl ether (DEGEE), is observed to be stabilized by an emulsifying wax blend of cetearyl alcohol, dicetyl phosphate, and ceteth-10 phosphate (tradename Crodafos CES). Polarized light microscopy indicates that the Crodafos CES helps to produce a liquid-crystal stabilized oil-in-water emulsion, which is physically stable for months under accelerated aging conditions and chemically stable over the full topical pH range of 3.5 to 9. Emulsion globule size in the cream is observed to be dependent on the degree of emulsifying wax neutralization, with the globule size decreasing with increasing cream pH. The superior solubilizing properties of DEGEE combined with the full pH range and liquid-crystal stabilizing properties of the Crodafos CES give this formulation the potential for a wide range of applications in the topical delivery of active pharmaceutical ingredients.