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Nazir, S.A., Khan, J.N., Mahmoud, I.Z., Greenwood, J.P., Blackman, D.J., Kunadian, V., Been, M., Abrams, K.R., Wilcox, R., Adgey, A.A.J., et al. (2016) The REFLO-STEMI (Reperfusion Facilitated by Local Adjunctive Therapy in ST-Elevation Myocardial Infarction) Trial: A Randomised Controlled Trial Comparing Intracoronary Administration of Adenosine or Sodium Nitroprusside with Control for Attenuation of Microvascular Obstruction during Primary Percutaneous Coronary Intervention.

has been cited by the following article:

• TITLE: Myocardial Infarction: An Overview of STEMI and NSTEMI Physiopathology and Treatment

  AUTHORS: J. G. Kingma

  KEYWORDS: Ischemia, Reperfusion, Infarction, Ischemia, No-Reflow, Microcirculation, Blood Flow, Ischemic Conditioning

  JOURNAL NAME: World Journal of Cardiovascular Diseases, Vol.8 No.11, November 12, 2018

  ABSTRACT: Patients with myocardial infarction resulting from acute coronary syndrome are classified by electrocardiographic presentation: 1-acute ST-segment elevation myocardial infarction (STEMI) or 2-non-ST-segment elevation myocardial infarction (NSTEMI). Prompt reperfusion of an infarct-related artery by percutaneous coronary interventions provides some relief of symptoms; long-term prognosis appears to be worse in STEMI compared to NSTEMI patients but clinical findings remain controversial. Reduced myocardial perfusion to the infarct area, caused in part by microvascular obstruction, is a privileged target for diverse pharmacologic or non-pharmacologic interventions (or combinations thereof) to improve clinical outcomes. To date, benefits of both pharmacologic and non-pharmacologic strategies to either limit microvascular obstruction and myocardial injury or improve myocardial perfusion are inconsistent. This review focuses on the physiopathological aspects of myocardial infarction in relation to development of STEMI/NSTEMI and on potential cardioprotective strategies.