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Olàh, G., Herédi, J., Menyhàrt, A., Czinege, Z., Nagy, D., Fuzik, J., Kocsis, K., Knapp, L., Krucsò, E., Gellért, L., Kis, Z., Farkas, T., Fulop, F., Pàrdutz, A., Tajti, J., Vécsei, L. and Toldi, J. (2013) Unexpected Effects of Peripherally Administered Kynurenic Acid on Cortical Spreading Depression and Related Blood-Brain Barrier Permeability. Drug Design, Development and Therapy, 16, 981-987

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• TITLE: Efficacy of a Combination of Tanacetum parthenium, 5-Hydroxy Tryptophan and Magnesium (Aurastop) in the Prevention of High Frequency Migraine with Aura

  AUTHORS: Giorgio Dalla Volta, Paola Zavarise, Laura Perego, Alessandro Pezzini

  KEYWORDS: Migraine Aura, Migraine Therapy, Case-Only Study

  JOURNAL NAME: Open Access Library Journal, Vol.5 No.10, October 30, 2018

  ABSTRACT: Object: To verify the efficacy and safety of the new combination of Tanacetum parthenium 150 mg, 5-hydrossitriptophan (5-HTTP) 20 mg and magnesium 185 mg (Aurastop) in the prophylactic treatment of high frequency migraine with aura (MWA). According to the international headache classification (IHCD 3 beta version) the aura phenomena have a duration of 5 - 60 minutes for any of the usual disturbances (visual, somatosensory and speech disturbance) but no classification describes the frequency of this phenomena. Patients who experience migraine aura emphasize the emotional impact of such a phenomenon, mostly because of the severe, though transient, disability caused by the aura symptoms (i.e., inability to work or driving a vehicle). Furthermore, a profound asthenia lasts for about 48 hours after the resolution of the painful phase. Materials and Method: 18 patients (F: n = 10, M: n = 8, mean age: 28) presenting with an ICHD-3 beta diagnosis of migraine with aura (MWA) with a frequency of more than 5 attacks of migraine with aura per month since at least 6 months, were enrolled in the survey and treated with Aurastop? twice a day for a period of 3 months. Diary cards were filled in during a 3-month period before the beginning of the survey and during the 3-month duration of the study. The reduction of MWA attacks per month was assessed as the primary end-point; the reduction of the duration and disability of the aura and of the intensity of the headache were considered as secondary end-points. Results: A statistically significant reduction of MWA attacks/month was observed: more than 95% of the patients referred a reduction >50% of the frequency, 66.6% a reduction of more than 70%, and 16.6% a complete disappearance of the attacks after the first week of therapy. Moreover, a sensible reduction of the duration and disability of the aura phenomena was reported by more than 90% of the patients and, in the 55% of the patients also a reduction of the intensity of the headache. No side effects were reported. The efficacy started to appear during the first month of intake and was maintained during the three months of therapy.