TITLE:
Sirtuins and Chronic Obstructive Pulmonary Disease
AUTHORS:
C. Carollo, C. Urso, R. Lo Presti, G. Caimi
KEYWORDS:
Sirtuins, Chronic Obstructive Pulmonary Disease, Resveratrol, Wine
JOURNAL NAME:
Food and Nutrition Sciences,
Vol.9 No.10,
October
30,
2018
ABSTRACT: Chronic obstructive pulmonary disease (COPD) is one of the world leading causes of death. It has been recently related to aging and inflammation, as well as sirtuins are actually recognized to be involved in both these phenomena. Sirtuins are a family of highly conserved protein deacetylases and they influence the factors that worsen physiological aging such as glucose metabolism, DNA stability and cancer, neurodegenerative processes, etc. Among the seven sirtuins, SIRT1 and SIRT6 have been deeply investigated in COPD. Actually researchers hypothesize that SIRT 1 activators could play a fundamental role in counteract COPD. Natural compounds as Resveratrol are actually retained SIRT1 activators and could be indicated as powerful weapons against this complex disease.