TITLE:
Combined Hepatocellular-Cholangiocarcinoma with Stem Cell Features—Case Report
AUTHORS:
Leonardo Verza, Carlos Henrique Rosas, Gabriel Marques Neves, Tércia Neves, Maria Dirlei Begnami, Marcos Duarte Guimarães
KEYWORDS:
Hepatocellular Carcinoma, Cholangiocarcinoma, Liver Neoplasm, Diagnostic Imaging
JOURNAL NAME:
Case Reports in Clinical Medicine,
Vol.7 No.10,
October
29,
2018
ABSTRACT: Combined hepatocholangiocarcinoma is a rare and unique form of primary hepatic neoplasm, expressing histopathological and phenotypic aspects of hepatocellularcarcinoma and cholangiocarcinoma in the same tumor. Diagnosis may be performed by imaging, showing typical features of both components. We present a case of a 55-year-old woman presenting with abdominal pain and a hepatic mass. The patient underwent surgery and combined hepatocholangiocarcinoma with stem cells features was confirmed on pathological analysis. There are no signs of recurrence to date. Combined hepatocholangiocarcinoma requires a preoperative diagnosis, since it is a unique entity with higher rates of local and lymph node recurrence, compared to isolated forms.