TITLE:
Study of Human Serum Albumin-SPIONs Loaded PLGA Nanoparticles for Protein Delivery
AUTHORS:
Sri Vidawati, Silvia Barbosa, Pablo Taboada, Eva Villar, Antonio Topete, Victor Mosquera
KEYWORDS:
Nanoparticles, PLGA, SPIONs, HSA
JOURNAL NAME:
Advances in Biological Chemistry,
Vol.8 No.5,
October
24,
2018
ABSTRACT: The Biodegradable nanoparticles from poly(lactic-co-glycolic acid) (PLGA)
have been extensively investigated for sustained and targeted/localized
delivery of different agents. Many parameters are required in the synthesis of
a biodegradable polymeric nanoparticle. We report the synthesis of human serum
albumin (HSA)-superparamagnetic iron oxide nanoparticles (SPIONs) loaded PLGA
nanoparticles. All nanoparticles were characterized using a TEM image, UV-Vis
spectroscopy measurements, Zeta Potential, and PPMS for magnetizations. This
study described and investigated the interesting phenomenon in the synthesis
development of HSA-SPIONs loaded PLGA nanoparticles. The result showed that the
stability of HSA-SPIONs loaded PLGA nanoparticles for potential applications
such as in protein delivery.