TITLE:
Prevalence of Helicobacter pylori and the Interest of Its Eradication during the Functional Dyspepsia
AUTHORS:
S. Adadi, B. Bennani, M. Elabkari, A. Ibrahimi, S. Alaoui, M. El Khadir, T. Harmouch, M. Mahmoud, C. Nejjari, D. Benajah
KEYWORDS:
Functional Dyspepsia, Helicobacter pylori, Sequential Treatment, Triple Therapy
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.6 No.10,
October
16,
2018
ABSTRACT: Functional dyspepsia
constitutes by its impact in quality
of life and socio-economic impact areal public health problem (40% of the adult population in the Western world). The prevalence
of infection with Helicobacter pylori (HP) in
patients with functional dyspepsia is about 30% - 70%. The aim of our study
is to observe the improvement of functional dyspepsia (FD) after Helicobacter
pylori (HP) eradication. Methods: This is a prospective study over a period of 68
months (May 2009 - January 2015). We included all patients aged over 15 years, with
functional dyspepsia defined by the Rome III criteria. The diagnosis of HP was made by histology
and/or PCR. Patients infected with HP were treated in single-blind: standard triple therapy
for 7 days or sequential treatment for 10 days. HP eradication control was
made after: 3 months, 6 months and one year of treatment. Results:
During the study period, 1190 patients were included of which 250 patients
(21%) were in functional
dyspepsia according to the Rome III criteria. The average age in patients with functional dyspepsia was
49 years [16 - 80], sex ratio M/F was
0.58 (N = 92/158). 60% of patients
were older than 45 years (N = 150). Chronic smoking was found in 20% of
patients (N = 50). One hundred and seventy five patients (70%) had HP infection
(N = 175). One hundred and sixty five patients received the treatment of Helicobacter
pylori (94.28%), 10 patients were lost to follow (5.71%). The eradication
of HP was obtained in 98.41% with sequential treatment versus 88.73%
with standard triple therapy (p = 0.026). All patients were reviewed at 3
months and 6 months after treatment, 86% were reviewed at 12 months (N = 143). Dyspeptic symptoms was
disappeared in 43% of our patients (N = 71) partial disappearance of
symptoms in
34.5% of cases (N = 57) persistence of symptoms in 22.42% of cases (N = 37). Conclusion: In
our study the prevalence of Helicobacter pylori infection in patients
with functional dyspepsia is high: 70%. Sequential therapy is better than the standard triple therapy in
the eradication of HP in patients with nonulcer dyspepsia, which
improves their symptoms in more than 50% of cases.