TITLE:
Association of Tetanus-Diphtheria Vaccination during Pregnancy with Preeclampsia
AUTHORS:
Kubilay Canga, Pervin Karlı, Ayşe Zehra Özdemir, Mesut Önal, İdris Koçak
KEYWORDS:
Preeclampsia, Tetanus-Diphtheria Vaccination, Vaccination in Pregnancy, Vaccination, Pregnancy
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.8 No.12,
October
12,
2018
ABSTRACT: Introduction: The tetanus-diphtheria vaccine administered during
pregnancy is used as a toxoid vaccine with an intact antigen structure. In this
study, we investigated the association of tetanus-diphtheria vaccination (TDV)
during pregnancy with adverse maternal and neonatal outcomes and particularly
preeclampsia that may occur during pregnancy. Materials and Methods: From
the patients who presented to our clinic between 01.01.2016 and 31.12.2016 and
underwent a cesarean section, a total of 435 patients, 327 who received TDV and
108 who did not receive TDV, were included in the study. The groups were
compared with respect to their demographic characteristics. The patient data on
the gestational week, birth weight, normal newborn, preeclampsia, small for
gestational age (SGA), early membrane rupture, preterm labor, diabetic mother’s
baby, prematurity, temporary neonatal tachypnea, newborn’s need for intensive
care, and neonatal mortality were recorded. Results: While 14.7% of the
women who had been administered TDV had preeclampsia diagnosis during their
pregnancy, 12% of those who had not been vaccinated were diagnosed with
preeclampsia. This showed no significant correlation between having been
vaccinated during pregnancy and preeclampsia (p = 0.474).
The other outcomes we had specified had also no statistically significant
correlations with vaccination during pregnancy. Having been vaccinated during
pregnancy was found correlated only with the place of residence and nulliparity
(p = 0.004 and p = 0.002, respectively). Conclusion: No correlation was found in the study between TDV during pregnancy and
preeclampsia. According to the data obtained from this study, vaccination was
found to have no negative effect on preeclampsia or the other outcomes.