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Mironoy, A.N., Goryachev, D.V. and Garvishina, E.V. (2015) Specific Anti-IIa Activity is a Key Indicator of Safety and Efficacy in Validation of Biosimilarity of Unfractioned Heparin Preparations. Bulletin of Experimental Biology and Medicine, 158, 450-452.
https://doi.org/10.1007/s10517-015-2782-3

has been cited by the following article:

• TITLE: Heparin Sodium Was Prepared from Pig Intestinal Mucosa by Dialysis and Spray Drying

  AUTHORS: Shunshun Shu, Qian Mi, Caixia Yang, Chonghuan Bao, Zhaoyang Wang, Jun Niu

  KEYWORDS: Heparin Sodium, Dialysis and Spray Drying, Oven Drying Method, The Production Process

  JOURNAL NAME: Journal of Biosciences and Medicines, Vol.6 No.10, October 10, 2018

  ABSTRACT: A method to extract crude heparin sodium from pig intestinal mucosa by dialysis and spray drying was established. The pig intestinal mucosa was treated in the following steps: enzymolysis, resin exchange adsorption-washing, elution, pressure filtration, dialysis, spray drying. Activity of the product was measured using a heparin anti-IIa factor assay kit. The yield of crude heparin obtained by this method was 2.79% higher than that of oven drying method; the production of 1 kg crude heparin sodium saved 43.4 pigs small intestine. The activity was 98.48 ± 2.49 IU/mg (n = 5), 15.18 IU/mg higher than that obtained by oven drying method. The product is pale white powder, attractive color and easy to dissolve.