TITLE:
Efficacy and Safety of the Skin Adhesive EpinexusTM in Surgical Patients
AUTHORS:
Noriko Aramaki-Hattori, Keisuke Okabe, Yoshiaki Sakamoto, Shigeki Sakai, Tetsu Hayashida, Maiko Takahashi, Tomoko Seki, Yuko Kitagawa, Hiromitsu Jinno, Kazuo Kishi
KEYWORDS:
Acrylate Skin Adhesive, Single-Center, Comparative Randomized Control Study, Cosmetic Outcome
JOURNAL NAME:
Modern Plastic Surgery,
Vol.8 No.4,
October
8,
2018
ABSTRACT: This single-center, randomized, and controlled intervention study compared an acrylate skin adhesive, EpinexusTM (Mitsui Chemicals, Inc., Tokyo) with Dermabond AdvancedR (Ethicon, Inc., Somerville, New Jersey). The primary endpoint was cosmetic outcome at 52 weeks after treatment (Manchester Scar Scale), and the secondary endpoints were cosmetic outcome at 4 and 26 weeks after treatment (Manchester Scar Scale), wound closure, and usability. We evaluated 59 patients (29 cases and 30 controls). Failures and adverse events were also evaluated, and 8 adverse events (5 cases and 3 controls) were reported (epidermolysis, n = 4; contact dermatitis, n = 1; eczema, n = 1; and surgical wound dehiscence, n = 2). No difference was observed between groups in cosmetic outcome at 52 and 24 weeks; however, at 4 weeks, cases showed better cosmetic outcome compared with controls. With regard to usability, the treatment duration and application time were significantly longer with EpinexusTM, and ease of application
was significantly better with Dermabond AdvancedR.