TITLE:
Efficacy and Compliance of Oral Iron Poly-Maltose Complex versus Oral Ferrous Sulfate in the Treatment of Iron Deficiency Anemia in Pregnant Women
AUTHORS:
Mohamed A. Elsenity, Rehab M. Abdelrahman, Ayman M. Abdelkader, Maha M. Kamel
KEYWORDS:
Iron Deficiency Anemia, Iron Poly-Maltose Complex, Ferrous Sulfate
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.8 No.11,
September
29,
2018
ABSTRACT: Objective: To compare the efficacy and compliance of the
conventional therapy of iron deficiency anemia (ferrous sulfate) with the new
forms of therapy chewable iron tablets: (iron polymaltose complex) in the
treatment of iron deficiency anemia in pregnant women. Methods: This Randomized Control Trial study included 290
pregnant women with iron deficiency anemia, and they were randomly allocated to a control
group who received ferrous sulfate capsules for two months and study group who
received iron polymaltose complex chewable tablets for two months. Complete
Blood Picture (hemoglobin level and hematocrit level) and Serum ferritin level
were done after four and eight weeks to determine the efficacy. In addition,
any complains or side effects had been reported to assess the tolerability of
the drugs. Two-factor repeated-measures analysis of variance (ANOVA) was used to
compare the change in hemoglobin and serum ferritin levels in both groups. Results: There was no statistical significant difference
between the two research groups as regards baseline hemoglobin, and at week 4
from onset of treatment (p values = 0.990, 0.112, consecutively). However, there was statistical significant difference on
week 8 of continuous drug intake in both groups in which the iron poly maltose
complex research group had significantly higher hemoglobin levels (p value = 0.006). Conclusion: The results of the study showed oral iron
polymaltose complex increases Hemoglobin and serum ferritin levels more than
oral ferrous sulfate and produces less adverse effects than ferrous sulfate.