TITLE:
The Relationship of Age and Clinicopathologic Pattern to the Aggressiveness of Thyroid Cancer
AUTHORS:
Ibrahim Altedlawi AlBalawi
KEYWORDS:
Radioiodine Therapy, Thyroid Cancer, Thyroidectomy
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.9 No.9,
September
25,
2018
ABSTRACT: Objective: To study the relation of age and clinicopathologic
pattern to the aggressiveness of thyroid cancer cases and the treatment results
of patients from western region of Saudi Arabia with differentiated thyroid
carcinoma referred for treatment in King Abdulaziz Hospital and Oncology Center,
Jeddah, Saudi Arabia. Methods: Retrospective review of 174 patients with
differentiated thyroid carcinoma and analysis of the clinicopathologic
characteristics, age correlation to different risk factors, treatment protocol and
results were performed. Results: Analysis of the clinicopathologic
pattern showed no statistically significant difference between patients in the
different age groups except for extrathyroid extension and lymph node
involvement. Patients older than 45 years had a statistically significant lower incidence of
nodal involvement and a higher rate of extrathyroid extension (-131 dose of 200 mCi was used in 8 patients with
distant metastases. In 24 patients with radioiodine-avid cervical lymph nodes
and six patients with a gross residual tumor, an Iodine-131 dose of 150 mCi was used. For the whole study
group, the 5-year overall survival and disease-free survival were 96% and 88%. Conclusion: Despite the fact that differentiated thyroid
carcinoma is among the most curable cancer some patients are still at high risk
for recurrent and increased mortality.