TITLE:
Dissecting Emerging Aspects of Regulatory Circuitry in Man and Mice: Regulatory T Cell Biology
AUTHORS:
Tania Rahman, Md. Ferdous Seraj, Annelise Casellato
KEYWORDS:
Regulatory T Cells, Foxp3, tTreg, pTreg, IL-10, TGF-β, Helios, Neuropilin-1
JOURNAL NAME:
Advances in Bioscience and Biotechnology,
Vol.9 No.9,
September
18,
2018
ABSTRACT: Regulatory T cells (Treg), a
component of adaptive immunity, are well known for their immunosuppressive
roles and their ability to maintain the balance between the immunological and
pathological reactions. Treg have been shown to provide protective responses
and their depletion has resulted severe pathology in some pathogen infections.
The work presented here has unravelled the potential of regulatory cells in the
immune system including different repertoir of Treg cell subsets, markers to
distinguish them, Treg suppression mechanisms in the pathogenesis of various
infections and summarize different mouse models depleting Tregs. These findings
would help set up future avenues of research to elucidate a key mechanism of
action of these cells and provide new therapeutic insights for pathogenesis and
also for broader antibacterial/antiviral/antiproliferative immunity.