TITLE:
Synthesis, Antioxidant and Antimicrobial Activities of a Novel Series of Chalcones, Pyrazolic Chalcones, and Allylic Chalcones
AUTHORS:
Tan Nhut Doan, Dao Thanh Tran
KEYWORDS:
AllylicChalcones, Antioxidant Activity, Antimicrobial Activity, PyrazolicChalcones
JOURNAL NAME:
Pharmacology & Pharmacy,
Vol.2 No.4,
October
18,
2011
ABSTRACT: A new series of chalcones (4a-c) and allylicchalcones (11a-b) have been prepared by the Claisen-Schmidt condensation. A novel series of pyrazolicchalcones (5a-c) have been synthesized by the reaction of respective chalcones (4a-c) and hydrazine hydrate. The structures of the compounds were confirmed by spectral data (infrared spectroscopy and 1H nuclear magnetic resonance). All of the compounds (4/5a-c and 11a-b) have been tested for their antimicrobial activities (agar disc-diffusion method) and antioxidant activities (1,1-biphenyl-2-picrylhydrazyl free radical scavenging method). The test compounds failed to show antibacterial properties (4a-c, 5b, and 11a-b) or exhibited such properties poorly (5a and 5c). None of the test compounds displayed antifungal properties. Of the compounds tested, compounds 5a-c and 11a-b exhibited promising antioxidant activities.