TITLE:
The Serum 25(OH)D Level in Patients with Atypical Femoral Fracture
AUTHORS:
Hiroyuki Tsuchie, Naohisa Miyakoshi, Yuji Kasukawa, Toshiaki Aizawa, Hidekazu Abe, Toyohito Segawa, Yoichi Shimada
KEYWORDS:
Fracture, 25(OH)D, Curvature, Femur
JOURNAL NAME:
Open Journal of Orthopedics,
Vol.8 No.9,
September
11,
2018
ABSTRACT: Objective:
Excessive curvature of the femur has been considered to be one of the factors
associated with atypical femoral fracture (AFF). Although we clarified that
femoral curvature was markedly influenced by a low vitamin D level, very few
studies have been conducted on the direct relationship between AFF and a serum
low level of vitamin D. Therefore, we compared the serum vitamin D level
between AFF and osteoporosis patients. Methods: A total of 48 consecutive AFFs
in 36 Japanese patients were retrospectively reviewed using the medical
records, and 12 consecutive AFFs in 9 patients (AFF group) whose
25-hydroxyvitamin D (25(OH)D) levels were examined were included in this study.
As a non-AFF control group, 45 consecutive age-matched female patients with
osteoporosis (Osteoporosis group) were enrolled. We compared some laboratory
examination items, the bone mineral density, and curvature of the femur.
Results: When univariate logistic regression analysis was performed to compare
the 2 groups, Ca levels and lateral
and anterior curvatures in the AFF group were significantly greater than in the
Osteoporosis group (P