TITLE:
Association of Polymorphic Variants of VEGF and KDR Genes with Development and Metastasing of Non-Small Cell Lung Cancer
AUTHORS:
А. N. Shchayuk, E. V. Krupnova, M. N. Shapetska, A. P. Mikhalenka, N. V. Chebotareva, A. V. Kilchevsky
KEYWORDS:
Non-Small Cell Lung Cancer, Angiogenesis, Vascular Endothelial Growth Factor, VEGF Gene Polymorphism, KDR Gene Polymorphism
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.9 No.9,
September
11,
2018
ABSTRACT: Vascular endothelial growth factor (VEGF) is one of
the most important and specific factors affecting angiogenesis in tumor
development. VEGFR2 is a receptor encoded by the KDR gene. VEGF and VEGFR2 transmit a signal to intracellular
tyrosine kinase cascades. Polymorphic variants of the VEGF and KDR genes
significantly influence the expression levels of the endothelial growth factor
and its receptor, which leads to a change in the activation of angiogenesis in
oncopathological processes. In this study, the relationship between the
polymorphic variants rs2010963, rs699947 and rs3025039 of the VEGF gene and rs1870377 and rs2071559 of
the KDR gene was analyzed with the
development of a specific histological type of non-small cell lung cancer and
its clinical and morphological characteristics. It was established that the
development of squamous cell carcinoma is associated with -634CC genotype of
the VEGF gene and the genotypes
containing -2578A allele of the VEGF gene
reduce the likelihood of this cancer type development. The development of
adenocarcinoma is associated with +936CC VEGF/1719TT KDR and +936CT VEGF/1719TT KDR combinations.
In women with non-small cell lung cancer, -634GC genotype of the VEGF gene is associated with a greater
degree of the primary lesion spread. Genotype -2578СС of the VEGF gene is associated with a higher degree of the primary tumor spread in the
general group of patients and with regional metastases in women. Haplotypes
-634G/-2578C/+936C are risky for the occurrence of metastases in regional lymph
nodes in women.