TITLE:
Liposomal Iron for Iron Deficiency Anemia in Women of Reproductive Age: Review of Current Evidence
AUTHORS:
Parag Biniwale, Bhaskar Pal, Tripura Sundari, Gorakh Mandrupkar, Nikhil Datar, Amandeep Singh Khurana, Amit Qamra, Salman Motlekar, Rishi Jain
KEYWORDS:
Liposomal Iron, Microencapsulated, Micronized, Iron Deficiency, Anemia, Pregnancy
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.8 No.11,
September
11,
2018
ABSTRACT: Iron deficiency anemia is the most frequent nutritional deficiency
disorder. Conventionally administered oral iron is associated with
gastrointestinal intolerance that affects the outcomes and compliance. Liposomal iron is associated with
increased absorption without causing significant adverse effects. In this
review, we have discussed the technology of liposomal iron preparation,
mechanisms of its absorption and clinical evidence on its utility in iron deficiency
states in pregnant and non-pregnant women. Based on the available evidence, we
compared liposomal iron to conventional oral iron. Encapsulation of micronized
iron in liposomes is associated with lesser exposure to gastric contents,
lesser interaction with food contents, no exposure to different digestive
juices, targeted delivery of iron and allows lower doses to be administered in
lieu of direct absorption without need for protein carriers. The available
evidence suggests that liposomal iron significantly increases hemoglobin,
ferritin levels in pregnant women as well as in women with iron deficiency.