TITLE:
Factors Associated with Non-Adherence to Antiretroviral Therapy among HIV-Infected Adolescents at Pediatric Department of Yopougon University Hospital, Côte d’Ivoire
AUTHORS:
Tanoh Kassi François Eboua, Marcellin Nouaman, Marie-Hélène Ake-Assi, Yvette Bleu, Bherat Kouadio, Ekou Niamien, Laurence Adonis-Koffy
KEYWORDS:
Adolescent, Adherence, Antiretroviral Treatment, Cote d’Ivoire
JOURNAL NAME:
Open Journal of Pediatrics,
Vol.8 No.3,
September
6,
2018
ABSTRACT: Context: The consequences of non-adherence to antiretroviral therapy (ART) are
harmful in terms of morbidity and mortality among HIV-infected adolescents.
There is a little data in this population in West Africa, about non-adherence
to ART. Objective: To identify factors associated with non-adherence to
ART in adolescents at the Pediatric Ambulatory Treatment Center (PATC) of the
pediatric department of Yopougon University Hospital. Materials
and Methods: A cross-sectional
study was conducted from May to July 2017 among adolescents aged 10 to 19 years
old at PATC of pediatrics department of Yopougon University Hospital. We have
considered that adolescent was not adherent to ART when he affirm that he have
not taking ART at least once in the week before the survey. A logistic regression model was used to identify
factors associated with non-adherence to ART. Results: Overall 166
adolescents were included. The median age was 15 years old [IQI = 13 - 17 years]. They had a detectable viral load greater
than 1000 copies/ml in 41.8% of cases. The rate of non-adherence to ART was
40.4%. The factors associated with non-adherence to ART were male [OR = 2.5 (CI
= 1.1 - 10.0)], having parent widowed [OR = 7.8 (CI = 1.6 - 39.3)] or divorced
[RC= 3.7 (IC=1.1 - 13.5)], CD4 inclusion rate ≥ 500 cells/ml [OR = 8.5
(CI = 1.6 - 45.5)] and duration on ART ≥ 10 years [OR = 8.9 (CI = 1.6 - 50)]. Conclusion: A rigorous therapeutic education taking into account associated factors in this
study is necessary to reduce the rate of non-adherence among adolescents at
PATC.