TITLE:
The Cancer Patient Drowns in the Waves of Homeostatic Disorder
AUTHORS:
Z. Douvlis
KEYWORDS:
Interference of Genomic Information Flows, Optimization of Neoplastic Dynamics, Asymmetric Catabolism, Lactate Gradient, Variability of Malignancy, Cachexia with Good Nourishment
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.9 No.9,
September
6,
2018
ABSTRACT: Neoplastic cells are formed as a result of reprogramming the gene
expression. It is only when these cells are classified as non-local by the
normal cells that confrontation occurs, and thus cancer begins as a disease.
The tumorogenic degradation of the skeletal muscle plays a highly important
role in the pathomechanism of the disease. It transforms a diminishing
differentiation into an increasing homeostatic disorder, and is forced to
provide energy to the malignant cells. This characterizes the completed form of
the pathomechanism. Blocking the pathomechanism is the goal of a therapy that
can be realized on two levels: At the level of reprogramming of the gene expression,
which initiates the formation of neoplastic cells, a “reprogramming” of the
reprogramming of gene expression could be achieved by altering the genomic flow
of information. Increased anabolism (corresponding to the nutrient surplus) as
well as increased catabolism (corresponding to nutrient) could lead to
respective changes of the flows of genomic information. These opposing flows in
a patient could be expected to result in interference or a shearing effect.
Patients with acromegaly exhibit a 9.25% increased neoplasia prevalence, whilst
patients with hyperthyroidism have 8.41% increased neoplasia prevalence.
Patients with acromegaly and hyperthyroidism have a lower prevalence of
neoplasia of 3.30%, i.e. the chance
of these patients not contracting cancer is three times greater than patients
with either only acromegaly or only hyperthyroidism. At the level of
tumorogenic degradation of skeletal muscle, inhibition of muscle degradation by
means of hypertriglyceridemia results in a significant prolongation of the life
of carcinoma patients. This is based on the fact that inhibition of muscle
degradation occurs after infusion of triglyceride emulsion. In the case of S. sanguinis bacteremia, there may be an
interaction between enzymes from S.
sanguinis, from the digestive tract and from the tumor. The source of
infection determines the inactivation of the tumor enzyme and thus suppresses
tumor development.