TITLE:
Vitamin D3: Association of Low Vitamin D3 Levels with Semen Abnormalities in Infertile Males
AUTHORS:
Anwar Ali Jamali, Bhojo Mal Tanwani, Ghulam Mustafa Jamali, Ameer Ali Jamali, Muhammad Ali Suhail, Jagdesh Kumar, Rajesh Kumar
KEYWORDS:
Vitamin D Deficiency, Sperm Motility, Male Infertility
JOURNAL NAME:
Advances in Sexual Medicine,
Vol.8 No.4,
August
27,
2018
ABSTRACT: Background: Insufficiency
of vitamin D is one of the utmost general health issues all over the globe,
including Pakistan; incompatible data are present on the possible
relationship among serum vitamin D values and quality of semen. Objective: Lack of
Vitamin D in body is related with a higher risk of various health problems
including infertility. In our setup no such type of study had been conducted in
the past on the relationship among serum vitamin D levels and infertility. This
study was aimed to investigate male subjects with infertility and serum levels
of vitamin D. Methods: This
study was cross-sectional
and performed on 243 male subjects who attended the clinic for
evaluation of infertility from January 2016 to December 2017. Mean age of
patients was 31.94 years with standard deviation of 7.52 years. The mean age of
controls was 32.2 years with SD 8.42 years, age ranged between 20 years as
minimum to 46 years as maximum. The minimum vitamin D level was 7.00 ng/dl
while maximum 130 ng/dl, mean was 26.20 and
standard deviation was 22.06 ng/ml. Levels of vitamin D were significantly low in
(67%) male subjects with infertility. The mean vitamin D level of controls was
49.40 with SD of 35.98 ng/ml. 28% of controls had also vitamin D levels below
the normal range, which indicates the prevalence of vitamin D deficiency in
general population here in our setup. The participants were divided according
to WHO (World Health Organization) 2010 criteria along with corresponding
healthy control subjects. A questionnaire for evaluation of infertility in male
subjects was filled by all the contestants. Results: Levels of vitamin D
were significantly low in (67%) male subjects with infertility. While 28% of
controls had also vitamin D levels below the normal range. Infertile male subjects
with low or no sperm count were found insufficient for vitamin D in comparison
to healthy control subjects. Conclusion: It was concluded from the
results of current study that low levels of vitamin D are related with abnormal
male reproductive function, the severity of that was subject to the amount of
vitamin D insufficiency.